Research Advances in Cell Durotaxis

YANG Yuehua; JIANG Hongyuan

doi:10.21656/1000-0887.420265

Volume 42 Issue 10

Oct. 2021

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YANG Yuehua, JIANG Hongyuan. Research Advances in Cell Durotaxis[J]. Applied Mathematics and Mechanics, 2021, 42(10): 999-1007. doi: 10.21656/1000-0887.420265

Citation:

YANG Yuehua, JIANG Hongyuan. Research Advances in Cell Durotaxis[J]. Applied Mathematics and Mechanics, 2021, 42(10): 999-1007. doi: 10.21656/1000-0887.420265

Citation:

YANG Yuehua, JIANG Hongyuan. Research Advances in Cell Durotaxis[J]. Applied Mathematics and Mechanics, 2021, 42(10): 999-1007. doi: 10.21656/1000-0887.420265

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Research Advances in Cell Durotaxis

doi: 10.21656/1000-0887.420265

YANG Yuehua,
JIANG Hongyuan^,

CAS Key Laboratory of Mechanical Behavior and Design of Materials，Department of Modern Mechanics, School of Engineering Science, University of Science and Technology of China, Hefei 230026, P.R.China

Funds:

The National Natural Science Foundation of China(12002338

12025207

11872357)

Received Date: 2021-09-03
Rev Recd Date: 2021-09-10

Abstract

Abstract

The cellular mechanical microenvironment can regulate many cellular physiological functions. In particular, cells can migrate directionally under external cue gradients from their mechanical microenvironment. These directed migrations play critical roles in wound healing, cancer cell metastasis, and tissue morphology development. So far, directional cell migration mostly includes: the directional migration under chemical gradients (chemotaxis), the directional migration under adhesion gradients (haptotaxis), and the directional migration under mechanical gradients (durotaxis). Although the basic mechanisms of chemotaxis and haptotaxis are well characterized, the mechanism of durotaxis remains unclear. In this review, we describe the experimental and theoretical advances in the study of cell durotaxis, analyze the connections and differences among different studies, discuss the potential mechanical mechanism of cell durotaxis, and put forward the remaining problems and possible future research directions.
- cellular mechanical microenvironment,
- directional cell migration,
- cell durotaxis,
- volume regulation,
- cell polarity

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References(63)

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